A Genome-Wide Screen of Deletion Mutants in the Filamentous <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis
ABSTRACT Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. H...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/5a846ae95af84dc7bb22353437472831 |
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