A Genome-Wide Screen of Deletion Mutants in the Filamentous <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

A Genome-Wide Screen of Deletion Mutants in the Filamentous <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

ABSTRACT Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. H...

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Autores principales: Kristy Koselny, Nebibe Mutlu, Annabel Y. Minard, Anuj Kumar, Damian J. Krysan, Melanie Wellington
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Candida albicans
inflammasome
pyroptosis
Microbiology
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Acceso en línea:https://doaj.org/article/5a846ae95af84dc7bb22353437472831
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