Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Tumour necrosis is associated with tumour aggressiveness and poor outcomes in patients with glioblastomas, but the underlying mechanisms remain poorly understood. Here, the authors show that in a xenograft mouse model of glioblastoma, tumour-infiltrating neutrophils amplify necrosis by promoting mye...

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Autores principales:	Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong-Gang Wang, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5aa48c67defa41babccc7a4dbd4c5fc0
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spelling	oai:doaj.org-article:5aa48c67defa41babccc7a4dbd4c5fc02021-12-02T14:40:51ZNeutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression10.1038/s41467-020-19193-y2041-1723https://doaj.org/article/5aa48c67defa41babccc7a4dbd4c5fc02020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19193-yhttps://doaj.org/toc/2041-1723Tumour necrosis is associated with tumour aggressiveness and poor outcomes in patients with glioblastomas, but the underlying mechanisms remain poorly understood. Here, the authors show that in a xenograft mouse model of glioblastoma, tumour-infiltrating neutrophils amplify necrosis by promoting myeloperoxidase-induced tumour cell ferroptosis.Patricia P. YeeYiju WeiSoo-Yeon KimTong LuStephen Y. ChihCynthia LawsonMiaolu TangZhijun LiuBenjamin AndersonKrishnamoorthy ThamburajMegan M. YoungDawit G. AregawiMichael J. GlantzBrad E. ZachariaCharles S. SpechtHong-Gang WangWei LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia P. Yee Yiju Wei Soo-Yeon Kim Tong Lu Stephen Y. Chih Cynthia Lawson Miaolu Tang Zhijun Liu Benjamin Anderson Krishnamoorthy Thamburaj Megan M. Young Dawit G. Aregawi Michael J. Glantz Brad E. Zacharia Charles S. Specht Hong-Gang Wang Wei Li Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
description	Tumour necrosis is associated with tumour aggressiveness and poor outcomes in patients with glioblastomas, but the underlying mechanisms remain poorly understood. Here, the authors show that in a xenograft mouse model of glioblastoma, tumour-infiltrating neutrophils amplify necrosis by promoting myeloperoxidase-induced tumour cell ferroptosis.
format	article
author	Patricia P. Yee Yiju Wei Soo-Yeon Kim Tong Lu Stephen Y. Chih Cynthia Lawson Miaolu Tang Zhijun Liu Benjamin Anderson Krishnamoorthy Thamburaj Megan M. Young Dawit G. Aregawi Michael J. Glantz Brad E. Zacharia Charles S. Specht Hong-Gang Wang Wei Li
author_facet	Patricia P. Yee Yiju Wei Soo-Yeon Kim Tong Lu Stephen Y. Chih Cynthia Lawson Miaolu Tang Zhijun Liu Benjamin Anderson Krishnamoorthy Thamburaj Megan M. Young Dawit G. Aregawi Michael J. Glantz Brad E. Zacharia Charles S. Specht Hong-Gang Wang Wei Li
author_sort	Patricia P. Yee
title	Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
title_short	Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
title_full	Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
title_fullStr	Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
title_full_unstemmed	Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
title_sort	neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5aa48c67defa41babccc7a4dbd4c5fc0
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Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

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