The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

Osteoarthritis involves whole-joint tissue degeneration. Here, the authors show that miR-204 and miR-211 in mesenchymal joint cells regulate their proliferation, catabolic and osteogenic responses, and that disease progression is ameliorated by intra-articular miR-204 delivery in mice.

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Detalles Bibliográficos
Autores principales: Jian Huang, Lan Zhao, Yunshan Fan, Lifan Liao, Peter X. Ma, Guozhi Xiao, Di Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5aae4a0d105542e7914d2239eb10e034
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