The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

Osteoarthritis involves whole-joint tissue degeneration. Here, the authors show that miR-204 and miR-211 in mesenchymal joint cells regulate their proliferation, catabolic and osteogenic responses, and that disease progression is ameliorated by intra-articular miR-204 delivery in mice.

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Autores principales:	Jian Huang, Lan Zhao, Yunshan Fan, Lifan Liao, Peter X. Ma, Guozhi Xiao, Di Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5aae4a0d105542e7914d2239eb10e034
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spelling	oai:doaj.org-article:5aae4a0d105542e7914d2239eb10e0342021-12-02T17:31:36ZThe microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression10.1038/s41467-019-10753-52041-1723https://doaj.org/article/5aae4a0d105542e7914d2239eb10e0342019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10753-5https://doaj.org/toc/2041-1723Osteoarthritis involves whole-joint tissue degeneration. Here, the authors show that miR-204 and miR-211 in mesenchymal joint cells regulate their proliferation, catabolic and osteogenic responses, and that disease progression is ameliorated by intra-articular miR-204 delivery in mice.Jian HuangLan ZhaoYunshan FanLifan LiaoPeter X. MaGuozhi XiaoDi ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Huang Lan Zhao Yunshan Fan Lifan Liao Peter X. Ma Guozhi Xiao Di Chen The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
description	Osteoarthritis involves whole-joint tissue degeneration. Here, the authors show that miR-204 and miR-211 in mesenchymal joint cells regulate their proliferation, catabolic and osteogenic responses, and that disease progression is ameliorated by intra-articular miR-204 delivery in mice.
format	article
author	Jian Huang Lan Zhao Yunshan Fan Lifan Liao Peter X. Ma Guozhi Xiao Di Chen
author_facet	Jian Huang Lan Zhao Yunshan Fan Lifan Liao Peter X. Ma Guozhi Xiao Di Chen
author_sort	Jian Huang
title	The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
title_short	The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
title_full	The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
title_fullStr	The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
title_full_unstemmed	The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression
title_sort	micrornas mir-204 and mir-211 maintain joint homeostasis and protect against osteoarthritis progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5aae4a0d105542e7914d2239eb10e034
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The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

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