Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but r...

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Autores principales: Pui Wang, Siu-Ying Lau, Shaofeng Deng, Pin Chen, Bobo Wing-Yee Mok, Anna Jinxia Zhang, Andrew Chak-Yiu Lee, Kwok-Hung Chan, Rachel Chun-Yee Tam, Haoran Xu, Runhong Zhou, Wenjun Song, Li Liu, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Zhiwei Chen, Kwok-Yung Yuen, Honglin Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5ab058d1b50b45a8b2e9e5a270db4d74
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Sumario:The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but reduced immunopathology in a hamster model of infection.

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