Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein
The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but r...
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2021
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oai:doaj.org-article:5ab058d1b50b45a8b2e9e5a270db4d742021-12-02T17:15:23ZCharacterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein10.1038/s41467-021-23166-02041-1723https://doaj.org/article/5ab058d1b50b45a8b2e9e5a270db4d742021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23166-0https://doaj.org/toc/2041-1723The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but reduced immunopathology in a hamster model of infection.Pui WangSiu-Ying LauShaofeng DengPin ChenBobo Wing-Yee MokAnna Jinxia ZhangAndrew Chak-Yiu LeeKwok-Hung ChanRachel Chun-Yee TamHaoran XuRunhong ZhouWenjun SongLi LiuKelvin Kai-Wang ToJasper Fuk-Woo ChanZhiwei ChenKwok-Yung YuenHonglin ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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| language |
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| spellingShingle |
Science Q Pui Wang Siu-Ying Lau Shaofeng Deng Pin Chen Bobo Wing-Yee Mok Anna Jinxia Zhang Andrew Chak-Yiu Lee Kwok-Hung Chan Rachel Chun-Yee Tam Haoran Xu Runhong Zhou Wenjun Song Li Liu Kelvin Kai-Wang To Jasper Fuk-Woo Chan Zhiwei Chen Kwok-Yung Yuen Honglin Chen Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| description |
The S1/S2 junction of the SARS-CoV-2 Spike protein is emerging as a key factor in virulence and pathogenesis. Here, the authors characterise an attenuated strain of SARS-CoV-2 with deletions in the critical S1/S2 junction and observe enhanced replication, generation of potent adaptive immunity but reduced immunopathology in a hamster model of infection. |
| format |
article |
| author |
Pui Wang Siu-Ying Lau Shaofeng Deng Pin Chen Bobo Wing-Yee Mok Anna Jinxia Zhang Andrew Chak-Yiu Lee Kwok-Hung Chan Rachel Chun-Yee Tam Haoran Xu Runhong Zhou Wenjun Song Li Liu Kelvin Kai-Wang To Jasper Fuk-Woo Chan Zhiwei Chen Kwok-Yung Yuen Honglin Chen |
| author_facet |
Pui Wang Siu-Ying Lau Shaofeng Deng Pin Chen Bobo Wing-Yee Mok Anna Jinxia Zhang Andrew Chak-Yiu Lee Kwok-Hung Chan Rachel Chun-Yee Tam Haoran Xu Runhong Zhou Wenjun Song Li Liu Kelvin Kai-Wang To Jasper Fuk-Woo Chan Zhiwei Chen Kwok-Yung Yuen Honglin Chen |
| author_sort |
Pui Wang |
| title |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| title_short |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| title_full |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| title_fullStr |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| title_full_unstemmed |
Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein |
| title_sort |
characterization of an attenuated sars-cov-2 variant with a deletion at the s1/s2 junction of the spike protein |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5ab058d1b50b45a8b2e9e5a270db4d74 |
| work_keys_str_mv |
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