Quantifying CDK inhibitor selectivity in live cells

Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhib...

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Main Authors:	Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
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spelling	oai:doaj.org-article:5ab2cf72cb7f4b5ea0a65e02f4e02daf2021-12-02T18:24:49ZQuantifying CDK inhibitor selectivity in live cells10.1038/s41467-020-16559-02041-1723https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16559-0https://doaj.org/toc/2041-1723Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.Carrow I. WellsJames D. VastaCesear R. CoronaJennifer WilkinsonChad A. ZimprichMorgan R. IngoldJulie E. PickettDavid H. DrewryKathryn M. PughMarie K. SchwinnByounghoon (Brian) HwangHicham ZegzoutiKilian V. M. HuberMei CongPoncho L. MeisenheimerTimothy M. WillsonMatthew B. RobersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers Quantifying CDK inhibitor selectivity in live cells
description	Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.
format	article
author	Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers
author_facet	Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers
author_sort	Carrow I. Wells
title	Quantifying CDK inhibitor selectivity in live cells
title_short	Quantifying CDK inhibitor selectivity in live cells
title_full	Quantifying CDK inhibitor selectivity in live cells
title_fullStr	Quantifying CDK inhibitor selectivity in live cells
title_full_unstemmed	Quantifying CDK inhibitor selectivity in live cells
title_sort	quantifying cdk inhibitor selectivity in live cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
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Quantifying CDK inhibitor selectivity in live cells

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