Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

ABSTRACT Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti-FHbp antibody response inhibited binding of human...

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Autores principales: Peter T. Beernink, Serena Giuntini, Isabella Costa, Alexander H. Lucas, Dan M. Granoff
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://doaj.org/article/5ab94d1bfd9a40c8ad446477965f1842
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