Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
ABSTRACT Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement. In wild-type mice whose mouse FH does not bind to FHbp vaccines, the serum anti-FHbp antibody response inhibited binding of human...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2015
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| Subjects: | |
| Online Access: | https://doaj.org/article/5ab94d1bfd9a40c8ad446477965f1842 |
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