The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry

The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry

Abstract The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is...

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Autores principales: Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Cheng, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun, Yongfeng Shang
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Medicine
R
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/5acff25e3c624ba6b2d4d4b321b45460
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https://doaj.org/article/5acff25e3c624ba6b2d4d4b321b45460

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