Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway

Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotective effects in numerous cardiovascular conditions, but its p...

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Autores principales: Yi Yang, Na Li, Tongshuai Chen, Chunmei Zhang, Lingxin Liu, Yan Qi, Peili Bu
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2019
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Acceso en línea:https://doaj.org/article/5ad1ba90404b445aadedc190f4a54bdf
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