In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection

Stress granules (SGs) are non-membrane ribonucleoprotein condensates formed in response to environmental stress conditions via liquid–liquid phase separation (LLPS). SGs are involved in the pathogenesis of aging and aging-associated diseases, cancers, viral infection, and several other diseases. GTP...

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Main Authors:	Bjad K. Almutairy, Abdullah Alshetaili, Md. Khalid Anwer, Nemat Ali
Format:	article
Language:	EN
Published:	Elsevier 2021
Subjects:	COVID-19 SARS-CoV-2 Nucleocapsid Stress granule G3BP microRNA Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/5af723e4b291473a996966e99bdff6ac
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spelling	oai:doaj.org-article:5af723e4b291473a996966e99bdff6ac2021-11-20T04:57:06ZIn silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection1319-562X10.1016/j.sjbs.2021.08.056https://doaj.org/article/5af723e4b291473a996966e99bdff6ac2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21007336https://doaj.org/toc/1319-562XStress granules (SGs) are non-membrane ribonucleoprotein condensates formed in response to environmental stress conditions via liquid–liquid phase separation (LLPS). SGs are involved in the pathogenesis of aging and aging-associated diseases, cancers, viral infection, and several other diseases. GTPase-activating protein (SH3 domain)-binding protein 1 and 2 (G3BP1/2) is a key component and commonly used marker of SGs. Recent studies have shown that SARS-CoV-2 nucleocapsid protein via sequestration of G3BPs inhibits SGs formation in the host cells. In this study, we have identified putative miRNAs targeting G3BP in search of modulators of the G3BP expression. These miRNAs could be considered as new therapeutic targets against COVID-19 infection via the regulation of SG assembly and dynamics.Bjad K. AlmutairyAbdullah AlshetailiMd. Khalid AnwerNemat AliElsevierarticleCOVID-19SARS-CoV-2NucleocapsidStress granuleG3BPmicroRNABiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7499-7504 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 Nucleocapsid Stress granule G3BP microRNA Biology (General) QH301-705.5
spellingShingle	COVID-19 SARS-CoV-2 Nucleocapsid Stress granule G3BP microRNA Biology (General) QH301-705.5 Bjad K. Almutairy Abdullah Alshetaili Md. Khalid Anwer Nemat Ali In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
description	Stress granules (SGs) are non-membrane ribonucleoprotein condensates formed in response to environmental stress conditions via liquid–liquid phase separation (LLPS). SGs are involved in the pathogenesis of aging and aging-associated diseases, cancers, viral infection, and several other diseases. GTPase-activating protein (SH3 domain)-binding protein 1 and 2 (G3BP1/2) is a key component and commonly used marker of SGs. Recent studies have shown that SARS-CoV-2 nucleocapsid protein via sequestration of G3BPs inhibits SGs formation in the host cells. In this study, we have identified putative miRNAs targeting G3BP in search of modulators of the G3BP expression. These miRNAs could be considered as new therapeutic targets against COVID-19 infection via the regulation of SG assembly and dynamics.
format	article
author	Bjad K. Almutairy Abdullah Alshetaili Md. Khalid Anwer Nemat Ali
author_facet	Bjad K. Almutairy Abdullah Alshetaili Md. Khalid Anwer Nemat Ali
author_sort	Bjad K. Almutairy
title	In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
title_short	In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
title_full	In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
title_fullStr	In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
title_full_unstemmed	In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
title_sort	in silico identification of micrornas targeting the key nucleator of stress granules, g3bp: promising therapeutics for sars-cov-2 infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5af723e4b291473a996966e99bdff6ac
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In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection

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