Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation...

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Autores principales:	Carman K. M. Ip, Patrick K. S. Ng, Kang Jin Jeong, S. H. Shao, Zhenlin Ju, P. G. Leonard, Xu Hua, Christopher P. Vellano, Richard Woessner, Nidhi Sahni, Kenneth L. Scott, Gordon B. Mills
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5afbb5f4318a4d348864297344880429
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spelling	oai:doaj.org-article:5afbb5f4318a4d3488642973448804292021-12-02T14:39:23ZNeomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies10.1038/s41467-018-06949-w2041-1723https://doaj.org/article/5afbb5f4318a4d3488642973448804292018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06949-whttps://doaj.org/toc/2041-1723Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation is resistant to PDGFRA targeted therapies.Carman K. M. IpPatrick K. S. NgKang Jin JeongS. H. ShaoZhenlin JuP. G. LeonardXu HuaChristopher P. VellanoRichard WoessnerNidhi SahniKenneth L. ScottGordon B. MillsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
description	Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation is resistant to PDGFRA targeted therapies.
format	article
author	Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills
author_facet	Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills
author_sort	Carman K. M. Ip
title	Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
title_short	Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
title_full	Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
title_fullStr	Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
title_full_unstemmed	Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
title_sort	neomorphic pdgfra extracellular domain driver mutations are resistant to pdgfra targeted therapies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5afbb5f4318a4d348864297344880429
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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

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