CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.

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Detalles Bibliográficos
Autores principales: Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
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https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e

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