CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.

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Autores principales:	Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5b062bd4e6884a5f96c38bd03af38f9e2021-12-02T16:51:09ZCD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells10.1038/s42003-021-02119-92399-3642https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02119-9https://doaj.org/toc/2399-3642Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.Yo-Ping LaiLu-Cheng KuoBeen-Ren LinHung-Ju LinChih-Yu LinYi-Ting ChenPei-Wen HsiaoHuan-Tsung ChangPatrick Chow-In KoHsiao-Chin ChenHsiang-Yu ChangJean LuHong-Nerng HoBetty A. Wu-HsiehJohn T. KungShu-Ching ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yo-Ping Lai Lu-Cheng Kuo Been-Ren Lin Hung-Ju Lin Chih-Yu Lin Yi-Ting Chen Pei-Wen Hsiao Huan-Tsung Chang Patrick Chow-In Ko Hsiao-Chin Chen Hsiang-Yu Chang Jean Lu Hong-Nerng Ho Betty A. Wu-Hsieh John T. Kung Shu-Ching Chen CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
description	Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.
format	article
author	Yo-Ping Lai Lu-Cheng Kuo Been-Ren Lin Hung-Ju Lin Chih-Yu Lin Yi-Ting Chen Pei-Wen Hsiao Huan-Tsung Chang Patrick Chow-In Ko Hsiao-Chin Chen Hsiang-Yu Chang Jean Lu Hong-Nerng Ho Betty A. Wu-Hsieh John T. Kung Shu-Ching Chen
author_facet	Yo-Ping Lai Lu-Cheng Kuo Been-Ren Lin Hung-Ju Lin Chih-Yu Lin Yi-Ting Chen Pei-Wen Hsiao Huan-Tsung Chang Patrick Chow-In Ko Hsiao-Chin Chen Hsiang-Yu Chang Jean Lu Hong-Nerng Ho Betty A. Wu-Hsieh John T. Kung Shu-Ching Chen
author_sort	Yo-Ping Lai
title	CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
title_short	CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
title_full	CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
title_fullStr	CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
title_full_unstemmed	CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells
title_sort	cd28 engagement inhibits cd73-mediated regulatory activity of cd8+ t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
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CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

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