Pathogenic Mitochondrial DNA Mutation Load Inversely Correlates with Malignant Features in Familial Oncocytic Parathyroid Tumors Associated with Hyperparathyroidism-Jaw Tumor Syndrome

Pathogenic Mitochondrial DNA Mutation Load Inversely Correlates with Malignant Features in Familial Oncocytic Parathyroid Tumors Associated with Hyperparathyroidism-Jaw Tumor Syndrome

While somatic disruptive mitochondrial DNA (mtDNA) mutations that severely affect the respiratory chain are counter-selected in most human neoplasms, they are the genetic hallmark of indolent oncocytomas, where they appear to contribute to reduce tumorigenic potential. A correlation between mtDNA mu...

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Bibliographic Details
Main Authors: Monica De Luise, Luisa Iommarini, Lorena Marchio, Greta Tedesco, Camelia Alexandra Coadă, Andrea Repaci, Daniela Turchetti, Maria Lucia Tardio, Nunzio Salfi, Uberto Pagotto, Ivana Kurelac, Anna Maria Porcelli, Giuseppe Gasparre
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
mitochondrial DNA mutations
familial oncocytic tumors
respiratory complexes
hyperparathyroidism-jaw tumor syndrome
parathyroid cancer
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/5b126784dc2b48678f3729341d82e54f
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https://doaj.org/article/5b126784dc2b48678f3729341d82e54f

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