KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations

Abstract The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been undetermined. Here, we disclose the interact...

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Autor principal: Tatu Pantsar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5b1c9467f57d40f7a97ffe6051ad08bb
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