Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

Abstract Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the development of treatment resistant diseas...

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Autores principales:	Matthew S. Dietz, Thomas L. Sutton, Brett S. Walker, Charles E. Gast, Luai Zarour, Sidharth K. Sengupta, John R. Swain, Jennifer Eng, Michael Parappilly, Kristen Limbach, Ariana Sattler, Erik Burlingame, Yuki Chin, Austin Gower, Jose L. Montoya Mira, Ajay Sapre, Yu-Jui Chiu, Daniel R. Clayburgh, SuEllen J. Pommier, Jeremy P. Cetnar, Jared M. Fischer, Jerry J. Jaboin, Rodney F. Pommier, Brett C. Sheppard, V. Liana Tsikitis, Alison H. Skalet, Skye C. Mayo, Charles D. Lopez, Joe W. Gray, Gordon B. Mills, Zahi Mitri, Young Hwan Chang, Koei Chin, Melissa H. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5b2e471d1c8144e4a081a30d60ac23cd
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spelling	oai:doaj.org-article:5b2e471d1c8144e4a081a30d60ac23cd2021-12-02T14:33:51ZRelevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors10.1038/s41598-021-93053-72045-2322https://doaj.org/article/5b2e471d1c8144e4a081a30d60ac23cd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93053-7https://doaj.org/toc/2045-2322Abstract Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the development of treatment resistant disease. We recently reported the identification of a novel tumor-derived cell population, circulating hybrid cells (CHCs), harboring attributes from both macrophages and neoplastic cells, including functional characteristics important to metastatic spread. These disseminated hybrids outnumber conventionally defined circulating tumor cells (CTCs) in cancer patients. It is unknown if CHCs represent a generalized cancer mechanism for cell dissemination, or if this population is relevant to the metastatic cascade. Herein, we detect CHCs in the peripheral blood of patients with cancer in myriad disease sites encompassing epithelial and non-epithelial malignancies. Further, we demonstrate that in vivo-derived hybrid cells harbor tumor-initiating capacity in murine cancer models and that CHCs from human breast cancer patients express stem cell antigens, features consistent with the potential to seed and grow at metastatic sites. Finally, we reveal heterogeneity of CHC phenotypes reflect key tumor features, including oncogenic mutations and functional protein expression. Importantly, this novel population of disseminated neoplastic cells opens a new area in cancer biology and renewed opportunity for battling metastatic disease.Matthew S. DietzThomas L. SuttonBrett S. WalkerCharles E. GastLuai ZarourSidharth K. SenguptaJohn R. SwainJennifer EngMichael ParappillyKristen LimbachAriana SattlerErik BurlingameYuki ChinAustin GowerJose L. Montoya MiraAjay SapreYu-Jui ChiuDaniel R. ClayburghSuEllen J. PommierJeremy P. CetnarJared M. FischerJerry J. JaboinRodney F. PommierBrett C. SheppardV. Liana TsikitisAlison H. SkaletSkye C. MayoCharles D. LopezJoe W. GrayGordon B. MillsZahi MitriYoung Hwan ChangKoei ChinMelissa H. WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew S. Dietz Thomas L. Sutton Brett S. Walker Charles E. Gast Luai Zarour Sidharth K. Sengupta John R. Swain Jennifer Eng Michael Parappilly Kristen Limbach Ariana Sattler Erik Burlingame Yuki Chin Austin Gower Jose L. Montoya Mira Ajay Sapre Yu-Jui Chiu Daniel R. Clayburgh SuEllen J. Pommier Jeremy P. Cetnar Jared M. Fischer Jerry J. Jaboin Rodney F. Pommier Brett C. Sheppard V. Liana Tsikitis Alison H. Skalet Skye C. Mayo Charles D. Lopez Joe W. Gray Gordon B. Mills Zahi Mitri Young Hwan Chang Koei Chin Melissa H. Wong Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
description	Abstract Metastatic progression defines the final stages of tumor evolution and underlies the majority of cancer-related deaths. The heterogeneity in disseminated tumor cell populations capable of seeding and growing in distant organ sites contributes to the development of treatment resistant disease. We recently reported the identification of a novel tumor-derived cell population, circulating hybrid cells (CHCs), harboring attributes from both macrophages and neoplastic cells, including functional characteristics important to metastatic spread. These disseminated hybrids outnumber conventionally defined circulating tumor cells (CTCs) in cancer patients. It is unknown if CHCs represent a generalized cancer mechanism for cell dissemination, or if this population is relevant to the metastatic cascade. Herein, we detect CHCs in the peripheral blood of patients with cancer in myriad disease sites encompassing epithelial and non-epithelial malignancies. Further, we demonstrate that in vivo-derived hybrid cells harbor tumor-initiating capacity in murine cancer models and that CHCs from human breast cancer patients express stem cell antigens, features consistent with the potential to seed and grow at metastatic sites. Finally, we reveal heterogeneity of CHC phenotypes reflect key tumor features, including oncogenic mutations and functional protein expression. Importantly, this novel population of disseminated neoplastic cells opens a new area in cancer biology and renewed opportunity for battling metastatic disease.
format	article
author	Matthew S. Dietz Thomas L. Sutton Brett S. Walker Charles E. Gast Luai Zarour Sidharth K. Sengupta John R. Swain Jennifer Eng Michael Parappilly Kristen Limbach Ariana Sattler Erik Burlingame Yuki Chin Austin Gower Jose L. Montoya Mira Ajay Sapre Yu-Jui Chiu Daniel R. Clayburgh SuEllen J. Pommier Jeremy P. Cetnar Jared M. Fischer Jerry J. Jaboin Rodney F. Pommier Brett C. Sheppard V. Liana Tsikitis Alison H. Skalet Skye C. Mayo Charles D. Lopez Joe W. Gray Gordon B. Mills Zahi Mitri Young Hwan Chang Koei Chin Melissa H. Wong
author_facet	Matthew S. Dietz Thomas L. Sutton Brett S. Walker Charles E. Gast Luai Zarour Sidharth K. Sengupta John R. Swain Jennifer Eng Michael Parappilly Kristen Limbach Ariana Sattler Erik Burlingame Yuki Chin Austin Gower Jose L. Montoya Mira Ajay Sapre Yu-Jui Chiu Daniel R. Clayburgh SuEllen J. Pommier Jeremy P. Cetnar Jared M. Fischer Jerry J. Jaboin Rodney F. Pommier Brett C. Sheppard V. Liana Tsikitis Alison H. Skalet Skye C. Mayo Charles D. Lopez Joe W. Gray Gordon B. Mills Zahi Mitri Young Hwan Chang Koei Chin Melissa H. Wong
author_sort	Matthew S. Dietz
title	Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
title_short	Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
title_full	Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
title_fullStr	Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
title_full_unstemmed	Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
title_sort	relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b2e471d1c8144e4a081a30d60ac23cd
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Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors

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