Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

Abstract In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine delivered through dissolvable microneedle patches (MNPs) was found to be safe and immunogenic. Here, we compare the humoral and cellular immunologic responses in a subset of participants receiving inf...

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Autores principales:	Nadine G. Rouphael, Lilin Lai, Sonia Tandon, Michele Paine McCullough, Yunchuan Kong, Sarah Kabbani, Muktha S. Natrajan, Yongxian Xu, Yerun Zhu, Dongli Wang, Jesse O’Shea, Amy Sherman, Tianwei Yu, Sebastien Henry, Devin McAllister, Daniel Stadlbauer, Surender Khurana, Hana Golding, Florian Krammer, Mark J. Mulligan, Mark R. Prausnitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5b49040c2002496f8128ac3623836663
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spelling	oai:doaj.org-article:5b49040c2002496f8128ac36238366632021-12-02T16:09:39ZImmunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial10.1038/s41541-021-00353-02059-0105https://doaj.org/article/5b49040c2002496f8128ac36238366632021-07-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00353-0https://doaj.org/toc/2059-0105Abstract In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine delivered through dissolvable microneedle patches (MNPs) was found to be safe and immunogenic. Here, we compare the humoral and cellular immunologic responses in a subset of participants receiving influenza vaccination by MNP to the intramuscular (IM) route of administration. We collected serum, plasma, and peripheral blood mononuclear cells in 22 participants up to 180 days post-vaccination. Hemagglutination inhibition (HAI) titers and antibody avidity were similar after MNP and IM vaccination, even though MNP vaccination used a lower antigen dose. MNPs generated higher neuraminidase inhibition (NAI) titers for all three influenza virus vaccine strains tested and triggered a larger percentage of circulating T follicular helper cells (CD4 + CXCR5 + CXCR3 + ICOS + PD-1+) compared to the IM route. Our study indicates that inactivated influenza virus vaccination by MNP produces humoral and cellular immune response that are similar or greater than IM vaccination.Nadine G. RouphaelLilin LaiSonia TandonMichele Paine McCulloughYunchuan KongSarah KabbaniMuktha S. NatrajanYongxian XuYerun ZhuDongli WangJesse O’SheaAmy ShermanTianwei YuSebastien HenryDevin McAllisterDaniel StadlbauerSurender KhuranaHana GoldingFlorian KrammerMark J. MulliganMark R. PrausnitzNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nadine G. Rouphael Lilin Lai Sonia Tandon Michele Paine McCullough Yunchuan Kong Sarah Kabbani Muktha S. Natrajan Yongxian Xu Yerun Zhu Dongli Wang Jesse O’Shea Amy Sherman Tianwei Yu Sebastien Henry Devin McAllister Daniel Stadlbauer Surender Khurana Hana Golding Florian Krammer Mark J. Mulligan Mark R. Prausnitz Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
description	Abstract In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine delivered through dissolvable microneedle patches (MNPs) was found to be safe and immunogenic. Here, we compare the humoral and cellular immunologic responses in a subset of participants receiving influenza vaccination by MNP to the intramuscular (IM) route of administration. We collected serum, plasma, and peripheral blood mononuclear cells in 22 participants up to 180 days post-vaccination. Hemagglutination inhibition (HAI) titers and antibody avidity were similar after MNP and IM vaccination, even though MNP vaccination used a lower antigen dose. MNPs generated higher neuraminidase inhibition (NAI) titers for all three influenza virus vaccine strains tested and triggered a larger percentage of circulating T follicular helper cells (CD4 + CXCR5 + CXCR3 + ICOS + PD-1+) compared to the IM route. Our study indicates that inactivated influenza virus vaccination by MNP produces humoral and cellular immune response that are similar or greater than IM vaccination.
format	article
author	Nadine G. Rouphael Lilin Lai Sonia Tandon Michele Paine McCullough Yunchuan Kong Sarah Kabbani Muktha S. Natrajan Yongxian Xu Yerun Zhu Dongli Wang Jesse O’Shea Amy Sherman Tianwei Yu Sebastien Henry Devin McAllister Daniel Stadlbauer Surender Khurana Hana Golding Florian Krammer Mark J. Mulligan Mark R. Prausnitz
author_facet	Nadine G. Rouphael Lilin Lai Sonia Tandon Michele Paine McCullough Yunchuan Kong Sarah Kabbani Muktha S. Natrajan Yongxian Xu Yerun Zhu Dongli Wang Jesse O’Shea Amy Sherman Tianwei Yu Sebastien Henry Devin McAllister Daniel Stadlbauer Surender Khurana Hana Golding Florian Krammer Mark J. Mulligan Mark R. Prausnitz
author_sort	Nadine G. Rouphael
title	Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
title_short	Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
title_full	Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
title_fullStr	Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
title_full_unstemmed	Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial
title_sort	immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase i trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5b49040c2002496f8128ac3623836663
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Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

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