MnTnHex-2-PyP<sup>5+</sup>, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways

MnTnHex-2-PyP<sup>5+</sup>, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways

Tumor migration and invasion induced by the epithelial-to-mesenchymal transition (EMT) are prerequisites for metastasis. Here, we investigated the inhibitory effect of a mimic of superoxide dismutase (SOD), cationic Mn(III) <i>ortho</i>-substituted <i>N</i>-n-hexylpyridylporp...

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Auteurs principaux: Sung-Won Shin, Changhoon Choi, Hakyoung Kim, Yeeun Kim, Sohee Park, Shin-Yeong Kim, Ines Batinic-Haberle, Won Park
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
manganese porphyrin
MnTnHex-2-PyP<sup>5+</sup>
SOD mimics
radiation therapy
metastasis
NRF2
Therapeutics. Pharmacology
RM1-950
Accès en ligne:https://doaj.org/article/5b507cbe7fe8409d8046bef1324cff8d
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https://doaj.org/article/5b507cbe7fe8409d8046bef1324cff8d

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