The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases of the IRG protein family. Experiments with mice genetically deficient in members of this family such as Irgm1(LRG-47), Irgm3(IGTP), and Irgd(IRG-47) has revealed a critical role in microbial clearance,...

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Main Authors: Oliver Liesenfeld, Iana Parvanova, Jens Zerrahn, Seong-Ji Han, Frederik Heinrich, Melba Muñoz, Frank Kaiser, Toni Aebischer, Thorsten Buch, Ari Waisman, Gaby Reichmann, Olaf Utermöhlen, Esther von Stebut, Friederike D von Loewenich, Christian Bogdan, Sabine Specht, Michael Saeftel, Achim Hoerauf, Maria M Mota, Stephanie Könen-Waisman, Stefan H E Kaufmann, Jonathan C Howard
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/5baf7e6b5cbb4c77a93f96997cbaf00b
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