A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YA...

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Auteurs principaux: Ines Jeric, Gabriele Maurer, Anna Lina Cavallo, Josipa Raguz, Enrico Desideri, Bartosz Tarkowski, Matthias Parrini, Irmgard Fischer, Kurt Zatloukal, Manuela Baccarini
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/5bc4b495b6cf4f9894441a93a6563ceb
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