PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

PDE6δ regulates the sorting of prenylated cargo proteins. Here Fansa et al. propose that the affinity of the interaction between PDE6δ and its cargo protein determines whether they are released by cytoplasmic or cilia-specific release factors ultimately determining their subcellular localization.

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Autores principales:	Eyad Kalawy Fansa, Stefanie Kristine Kösling, Eldar Zent, Alfred Wittinghofer, Shehab Ismail
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5be0353338e24137b59efef00b3ded86
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spelling	oai:doaj.org-article:5be0353338e24137b59efef00b3ded862021-12-02T14:39:32ZPDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity10.1038/ncomms113662041-1723https://doaj.org/article/5be0353338e24137b59efef00b3ded862016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11366https://doaj.org/toc/2041-1723PDE6δ regulates the sorting of prenylated cargo proteins. Here Fansa et al. propose that the affinity of the interaction between PDE6δ and its cargo protein determines whether they are released by cytoplasmic or cilia-specific release factors ultimately determining their subcellular localization.Eyad Kalawy FansaStefanie Kristine KöslingEldar ZentAlfred WittinghoferShehab IsmailNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eyad Kalawy Fansa Stefanie Kristine Kösling Eldar Zent Alfred Wittinghofer Shehab Ismail PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
description	PDE6δ regulates the sorting of prenylated cargo proteins. Here Fansa et al. propose that the affinity of the interaction between PDE6δ and its cargo protein determines whether they are released by cytoplasmic or cilia-specific release factors ultimately determining their subcellular localization.
format	article
author	Eyad Kalawy Fansa Stefanie Kristine Kösling Eldar Zent Alfred Wittinghofer Shehab Ismail
author_facet	Eyad Kalawy Fansa Stefanie Kristine Kösling Eldar Zent Alfred Wittinghofer Shehab Ismail
author_sort	Eyad Kalawy Fansa
title	PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
title_short	PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
title_full	PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
title_fullStr	PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
title_full_unstemmed	PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
title_sort	pde6δ-mediated sorting of inpp5e into the cilium is determined by cargo-carrier affinity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5be0353338e24137b59efef00b3ded86
work_keys_str_mv	AT eyadkalawyfansa pde6dmediatedsortingofinpp5eintotheciliumisdeterminedbycargocarrieraffinity AT stefaniekristinekosling pde6dmediatedsortingofinpp5eintotheciliumisdeterminedbycargocarrieraffinity AT eldarzent pde6dmediatedsortingofinpp5eintotheciliumisdeterminedbycargocarrieraffinity AT alfredwittinghofer pde6dmediatedsortingofinpp5eintotheciliumisdeterminedbycargocarrieraffinity AT shehabismail pde6dmediatedsortingofinpp5eintotheciliumisdeterminedbycargocarrieraffinity
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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

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