WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

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Autores principales: Vasilios Tsarouhas, Dan Liu, Georgia Tsikala, Alina Fedoseienko, Kai Zinn, Ryo Matsuda, Daniel D. Billadeau, Christos Samakovlis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/5be47f95eade47cbb57480612cb0e67d
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