WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

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Main Authors:	Vasilios Tsarouhas, Dan Liu, Georgia Tsikala, Alina Fedoseienko, Kai Zinn, Ryo Matsuda, Daniel D. Billadeau, Christos Samakovlis
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/5be47f95eade47cbb57480612cb0e67d
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spelling	oai:doaj.org-article:5be47f95eade47cbb57480612cb0e67d2021-12-02T15:36:18ZWASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis10.1038/s41467-019-10229-62041-1723https://doaj.org/article/5be47f95eade47cbb57480612cb0e67d2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10229-6https://doaj.org/toc/2041-1723The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.Vasilios TsarouhasDan LiuGeorgia TsikalaAlina FedoseienkoKai ZinnRyo MatsudaDaniel D. BilladeauChristos SamakovlisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
description	The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.
format	article
author	Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis
author_facet	Vasilios Tsarouhas Dan Liu Georgia Tsikala Alina Fedoseienko Kai Zinn Ryo Matsuda Daniel D. Billadeau Christos Samakovlis
author_sort	Vasilios Tsarouhas
title	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_short	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_full	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_fullStr	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_full_unstemmed	WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
title_sort	wash phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5be47f95eade47cbb57480612cb0e67d
work_keys_str_mv	AT vasiliostsarouhas washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT danliu washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT georgiatsikala washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT alinafedoseienko washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT kaizinn washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT ryomatsuda washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT danieldbilladeau washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis AT christossamakovlis washphosphorylationbalancesendosomalversuscorticalactinnetworkintegritiesduringepithelialmorphogenesis
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WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

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