HIF-1α overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction

Aims: Naturally secreted extracellular vesicles (EVs) play important roles in stem-mediated cardioprotection. This study aimed to investigate the cardioprotective function and underlying mechanisms of EVs derived from HIF-1α engineered mesenchymal stem cells (MSCs) in a rat model of AMI. Methods and...

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Autores principales: Qingjie Wang, Le Zhang, Zhiqin Sun, Boyu Chi, Ailin Zou, Lipeng Mao, Xu Xiong, JianGuang Jiang, Ling Sun, Wenwu Zhu, Yuan Ji
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/5bea22ab8ba9433c8cb453b9ae8fad67
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