Differential methylation of TCF7L2 promoter in peripheral blood DNA in newly diagnosed, drug-naïve patients with type 2 diabetes.

TCF7L2 is the susceptibility gene for Type 2 diabetes (T2D) with the largest effect on disease risk that has been discovered to date. However, the mechanisms by which TCF7L2 contributes to the disease remain largely elusive. In addition, epigenetic mechanisms, such as changes in DNA methylation patt...

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Autores principales: Silvia Canivell, Elena G Ruano, Antoni Sisó-Almirall, Belchin Kostov, Luis González-de Paz, Eduardo Fernandez-Rebollo, Felicia A Hanzu, Marcelina Párrizas, Anna Novials, Ramon Gomis
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/5c0fc83e670f44068e6edb0cae63a396
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