Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets

Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets

Type 2 diabetes mellitus (T2DM) is a socially important disease with only symptomatic therapy developed due to lack of knowledge about its pathogenesis and underlying mechanism. Insulin resistance (IR) is the first link of T2DM pathogenesis and results in decrease of ability of insulin to stimulate...

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Autores principales: Ivan I. Dedov, Vsevolod A. Tkachuk, Nikolai B. Gusev, Vladimir P. Shirinsky, Aleksandr V. Vorotnikov, Tatiana N. Kochegura, Aleksander Y. Mayorov, Marina V. Shestakova
Formato: article
Lenguaje:EN
RU
Publicado: Endocrinology Research Centre 2018
Materias:
insulin resistance
diabetes mellitus
hyperglycaemia
metabolic syndrome
brown fat
"beige" adipocytes
insulin
oxidative stress
molecular mechanisms
pkb/akt
prep1
pparγ, small heat shock proteins
endothelial dysfunction
Nutritional diseases. Deficiency diseases
RC620-627
Acceso en línea:https://doaj.org/article/5c1738b3a0bc4182853b0ade8b934222
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https://doaj.org/article/5c1738b3a0bc4182853b0ade8b934222

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