Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36

Siu et al use FRET imaging in neuronal cell lines to explore the interplay between the gap junction channel protein Connexin-36 (Cx36) and NMDA receptor and Pannexin 1-mediated calcium signaling. They demonstrate that an increase in intracellular calcium promotes binding of CaMKII to Cx36, leading t...

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Autores principales:	Ryan C. F. Siu, Anna Kotova, Ksenia Timonina, Christiane Zoidl, Georg R. Zoidl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5c1a64775f944aa7933d31f56d812d15
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spelling	oai:doaj.org-article:5c1a64775f944aa7933d31f56d812d152021-12-02T17:30:53ZConvergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-3610.1038/s42003-021-02230-x2399-3642https://doaj.org/article/5c1a64775f944aa7933d31f56d812d152021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02230-xhttps://doaj.org/toc/2399-3642Siu et al use FRET imaging in neuronal cell lines to explore the interplay between the gap junction channel protein Connexin-36 (Cx36) and NMDA receptor and Pannexin 1-mediated calcium signaling. They demonstrate that an increase in intracellular calcium promotes binding of CaMKII to Cx36, leading to increased gap junction opening, thus providing a pathway by which components of chemical and electrical synapses communicate.Ryan C. F. SiuAnna KotovaKsenia TimoninaChristiane ZoidlGeorg R. ZoidlNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ryan C. F. Siu Anna Kotova Ksenia Timonina Christiane Zoidl Georg R. Zoidl Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
description	Siu et al use FRET imaging in neuronal cell lines to explore the interplay between the gap junction channel protein Connexin-36 (Cx36) and NMDA receptor and Pannexin 1-mediated calcium signaling. They demonstrate that an increase in intracellular calcium promotes binding of CaMKII to Cx36, leading to increased gap junction opening, thus providing a pathway by which components of chemical and electrical synapses communicate.
format	article
author	Ryan C. F. Siu Anna Kotova Ksenia Timonina Christiane Zoidl Georg R. Zoidl
author_facet	Ryan C. F. Siu Anna Kotova Ksenia Timonina Christiane Zoidl Georg R. Zoidl
author_sort	Ryan C. F. Siu
title	Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
title_short	Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
title_full	Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
title_fullStr	Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
title_full_unstemmed	Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36
title_sort	convergent nmda receptor—pannexin1 signaling pathways regulate the interaction of camkii with connexin-36
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c1a64775f944aa7933d31f56d812d15
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Convergent NMDA receptor—Pannexin1 signaling pathways regulate the interaction of CaMKII with Connexin-36

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