Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS

Abstract Liquid droplets of aggregation-prone proteins, which become hydrogels or form amyloid fibrils, are a potential target for drug discovery. In this study, we proposed an experiment-guided protocol for characterizing the design grammar of peptides that can regulate droplet formation and aggreg...

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Autores principales: Kiyoto Kamagata, Rika Chiba, Ichiro Kawahata, Nanako Iwaki, Saori Kanbayashi, Kana Maeda, Hiroto Takahashi, Atsushi Hirano, Koji Fukunaga, Keisuke Ikeda, Tomoshi Kameda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5c28b549012a45df95489b66f2315847
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