Glutamine deprivation triggers NAGK-dependent hexosamine salvage

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation in the cell. Prior studies have identified the...

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Bibliographic Details
Main Authors: Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
hexosamine
pancreatic cancer
N-acetylglucosamine kinase
glutamine
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/5ce0bca35ac845fba57a2e6f6f790030
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