Gastric Microbiota beyond <i>H. pylori</i>: An Emerging Critical Character in Gastric Carcinogenesis
Gastric cancer (GC) is one of the global leading causes of cancer death. The association between <i>Helicobacter pylori</i>, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large popu...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
MDPI AG
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/5d0d18c0936d42a88e815c6778ecbbbf |
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| Summary: | Gastric cancer (GC) is one of the global leading causes of cancer death. The association between <i>Helicobacter pylori</i>, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than <i>H. pylori</i> in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-<i>H. pylori</i> gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored. |
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