A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.

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Autores principales: Yufeng Yu, Yong-Qiang Deng, Peng Zou, Qian Wang, Yanyan Dai, Fei Yu, Lanying Du, Na-Na Zhang, Min Tian, Jia-Nan Hao, Yu Meng, Yuan Li, Xiaohui Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Cheng-Feng Qin, Shibo Jiang, Lu Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5d0d78f0909846abbec0bbcc412bf026
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spelling oai:doaj.org-article:5d0d78f0909846abbec0bbcc412bf0262021-12-02T15:38:46ZA peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses10.1038/ncomms156722041-1723https://doaj.org/article/5d0d78f0909846abbec0bbcc412bf0262017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15672https://doaj.org/toc/2041-1723Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.Yufeng YuYong-Qiang DengPeng ZouQian WangYanyan DaiFei YuLanying DuNa-Na ZhangMin TianJia-Nan HaoYu MengYuan LiXiaohui ZhouJasper Fuk-Woo ChanKwok-Yung YuenCheng-Feng QinShibo JiangLu LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yufeng Yu
Yong-Qiang Deng
Peng Zou
Qian Wang
Yanyan Dai
Fei Yu
Lanying Du
Na-Na Zhang
Min Tian
Jia-Nan Hao
Yu Meng
Yuan Li
Xiaohui Zhou
Jasper Fuk-Woo Chan
Kwok-Yung Yuen
Cheng-Feng Qin
Shibo Jiang
Lu Lu
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
description Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.
format article
author Yufeng Yu
Yong-Qiang Deng
Peng Zou
Qian Wang
Yanyan Dai
Fei Yu
Lanying Du
Na-Na Zhang
Min Tian
Jia-Nan Hao
Yu Meng
Yuan Li
Xiaohui Zhou
Jasper Fuk-Woo Chan
Kwok-Yung Yuen
Cheng-Feng Qin
Shibo Jiang
Lu Lu
author_facet Yufeng Yu
Yong-Qiang Deng
Peng Zou
Qian Wang
Yanyan Dai
Fei Yu
Lanying Du
Na-Na Zhang
Min Tian
Jia-Nan Hao
Yu Meng
Yuan Li
Xiaohui Zhou
Jasper Fuk-Woo Chan
Kwok-Yung Yuen
Cheng-Feng Qin
Shibo Jiang
Lu Lu
author_sort Yufeng Yu
title A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
title_short A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
title_full A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
title_fullStr A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
title_full_unstemmed A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses
title_sort peptide-based viral inactivator inhibits zika virus infection in pregnant mice and fetuses
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5d0d78f0909846abbec0bbcc412bf026
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