The SecA motor generates mechanical force during protein translocation

The ATPase SecA drives Sec-dependent protein translocation across the bacterial plasma membrane. Here, the authors combine kinetic translocation measurements with single-molecule force spectroscopy and demonstrate that the SecA motor generates mechanical force to unfold and translocate preproteins.

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Detalles Bibliográficos
Autores principales:	Riti Gupta, Dmitri Toptygin, Christian M. Kaiser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d1da2b994af4bd8a77f34c5868db326
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spelling	oai:doaj.org-article:5d1da2b994af4bd8a77f34c5868db3262021-12-02T16:31:04ZThe SecA motor generates mechanical force during protein translocation10.1038/s41467-020-17561-22041-1723https://doaj.org/article/5d1da2b994af4bd8a77f34c5868db3262020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17561-2https://doaj.org/toc/2041-1723The ATPase SecA drives Sec-dependent protein translocation across the bacterial plasma membrane. Here, the authors combine kinetic translocation measurements with single-molecule force spectroscopy and demonstrate that the SecA motor generates mechanical force to unfold and translocate preproteins.Riti GuptaDmitri ToptyginChristian M. KaiserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Riti Gupta Dmitri Toptygin Christian M. Kaiser The SecA motor generates mechanical force during protein translocation
description	The ATPase SecA drives Sec-dependent protein translocation across the bacterial plasma membrane. Here, the authors combine kinetic translocation measurements with single-molecule force spectroscopy and demonstrate that the SecA motor generates mechanical force to unfold and translocate preproteins.
format	article
author	Riti Gupta Dmitri Toptygin Christian M. Kaiser
author_facet	Riti Gupta Dmitri Toptygin Christian M. Kaiser
author_sort	Riti Gupta
title	The SecA motor generates mechanical force during protein translocation
title_short	The SecA motor generates mechanical force during protein translocation
title_full	The SecA motor generates mechanical force during protein translocation
title_fullStr	The SecA motor generates mechanical force during protein translocation
title_full_unstemmed	The SecA motor generates mechanical force during protein translocation
title_sort	seca motor generates mechanical force during protein translocation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5d1da2b994af4bd8a77f34c5868db326
work_keys_str_mv	AT ritigupta thesecamotorgeneratesmechanicalforceduringproteintranslocation AT dmitritoptygin thesecamotorgeneratesmechanicalforceduringproteintranslocation AT christianmkaiser thesecamotorgeneratesmechanicalforceduringproteintranslocation AT ritigupta secamotorgeneratesmechanicalforceduringproteintranslocation AT dmitritoptygin secamotorgeneratesmechanicalforceduringproteintranslocation AT christianmkaiser secamotorgeneratesmechanicalforceduringproteintranslocation
_version_	1718383874215510016

The SecA motor generates mechanical force during protein translocation

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