Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients

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Detalles Bibliográficos
Autores principales: Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f
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https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f

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