Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients

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Autores principales:	Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f
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spelling	oai:doaj.org-article:5d2954b26f864ba8adc0c8b369f6670f2021-12-02T15:33:39ZManic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells10.1038/s41467-018-05385-02041-1723https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05385-0https://doaj.org/toc/2041-1723In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patientsErika López-ArribillagaVerónica RodillaCarlota ColomerAnna VertAmy SheltonJason H. ChengBing YanAbel Gonzalez-PerezMelissa R. JunttilaMar IglesiasFerran TorresJoan AlbanellAlberto VillanuevaAnna BigasChristian W. SiebelLLuís EspinosaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erika López-Arribillaga Verónica Rodilla Carlota Colomer Anna Vert Amy Shelton Jason H. Cheng Bing Yan Abel Gonzalez-Perez Melissa R. Junttila Mar Iglesias Ferran Torres Joan Albanell Alberto Villanueva Anna Bigas Christian W. Siebel LLuís Espinosa Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
description	In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients
format	article
author	Erika López-Arribillaga Verónica Rodilla Carlota Colomer Anna Vert Amy Shelton Jason H. Cheng Bing Yan Abel Gonzalez-Perez Melissa R. Junttila Mar Iglesias Ferran Torres Joan Albanell Alberto Villanueva Anna Bigas Christian W. Siebel LLuís Espinosa
author_facet	Erika López-Arribillaga Verónica Rodilla Carlota Colomer Anna Vert Amy Shelton Jason H. Cheng Bing Yan Abel Gonzalez-Perez Melissa R. Junttila Mar Iglesias Ferran Torres Joan Albanell Alberto Villanueva Anna Bigas Christian W. Siebel LLuís Espinosa
author_sort	Erika López-Arribillaga
title	Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
title_short	Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
title_full	Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
title_fullStr	Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
title_full_unstemmed	Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
title_sort	manic fringe deficiency imposes jagged1 addiction to intestinal tumor cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f
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Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

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