Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Abstract Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF14...

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Autores principales:	Jesse Bakke, William C. Wright, Anthony E. Zamora, Su Sien Ong, Yue-Ming Wang, Jessica D. Hoyer, Christopher T. Brewer, Paul G. Thomas, Taosheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d4c2271ee054f058107877188025ae7
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spelling	oai:doaj.org-article:5d4c2271ee054f058107877188025ae72021-12-02T11:40:30ZTranscription factor ZNF148 is a negative regulator of human muscle differentiation10.1038/s41598-017-08267-52045-2322https://doaj.org/article/5d4c2271ee054f058107877188025ae72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08267-5https://doaj.org/toc/2045-2322Abstract Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.Jesse BakkeWilliam C. WrightAnthony E. ZamoraSu Sien OngYue-Ming WangJessica D. HoyerChristopher T. BrewerPaul G. ThomasTaosheng ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jesse Bakke William C. Wright Anthony E. Zamora Su Sien Ong Yue-Ming Wang Jessica D. Hoyer Christopher T. Brewer Paul G. Thomas Taosheng Chen Transcription factor ZNF148 is a negative regulator of human muscle differentiation
description	Abstract Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.
format	article
author	Jesse Bakke William C. Wright Anthony E. Zamora Su Sien Ong Yue-Ming Wang Jessica D. Hoyer Christopher T. Brewer Paul G. Thomas Taosheng Chen
author_facet	Jesse Bakke William C. Wright Anthony E. Zamora Su Sien Ong Yue-Ming Wang Jessica D. Hoyer Christopher T. Brewer Paul G. Thomas Taosheng Chen
author_sort	Jesse Bakke
title	Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_short	Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_full	Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_fullStr	Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_full_unstemmed	Transcription factor ZNF148 is a negative regulator of human muscle differentiation
title_sort	transcription factor znf148 is a negative regulator of human muscle differentiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5d4c2271ee054f058107877188025ae7
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_version_	1718395582791286784

Transcription factor ZNF148 is a negative regulator of human muscle differentiation

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