An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.

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Detalles Bibliográficos
Autores principales: Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/5d6d86e0a27242f592c4fcf292d06534
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https://doaj.org/article/5d6d86e0a27242f592c4fcf292d06534

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