An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.

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Autores principales:	Leo Hanke, Laura Vidakovics Perez, Daniel J. Sheward, Hrishikesh Das, Tim Schulte, Ainhoa Moliner-Morro, Martin Corcoran, Adnane Achour, Gunilla B. Karlsson Hedestam, B. Martin Hällberg, Ben Murrell, Gerald M. McInerney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d6d86e0a27242f592c4fcf292d06534
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spelling	oai:doaj.org-article:5d6d86e0a27242f592c4fcf292d065342021-12-02T19:04:01ZAn alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction10.1038/s41467-020-18174-52041-1723https://doaj.org/article/5d6d86e0a27242f592c4fcf292d065342020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18174-5https://doaj.org/toc/2041-1723Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.Leo HankeLaura Vidakovics PerezDaniel J. ShewardHrishikesh DasTim SchulteAinhoa Moliner-MorroMartin CorcoranAdnane AchourGunilla B. Karlsson HedestamB. Martin HällbergBen MurrellGerald M. McInerneyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leo Hanke Laura Vidakovics Perez Daniel J. Sheward Hrishikesh Das Tim Schulte Ainhoa Moliner-Morro Martin Corcoran Adnane Achour Gunilla B. Karlsson Hedestam B. Martin Hällberg Ben Murrell Gerald M. McInerney An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
description	Here, Hanke et al. immunize an alpaca with SARS-CoV-2 spike protein domains and identify a nanobody that binds the receptor binding domain of spike in both the up and down conformations and sterically hinders ACE2 engagement.
format	article
author	Leo Hanke Laura Vidakovics Perez Daniel J. Sheward Hrishikesh Das Tim Schulte Ainhoa Moliner-Morro Martin Corcoran Adnane Achour Gunilla B. Karlsson Hedestam B. Martin Hällberg Ben Murrell Gerald M. McInerney
author_facet	Leo Hanke Laura Vidakovics Perez Daniel J. Sheward Hrishikesh Das Tim Schulte Ainhoa Moliner-Morro Martin Corcoran Adnane Achour Gunilla B. Karlsson Hedestam B. Martin Hällberg Ben Murrell Gerald M. McInerney
author_sort	Leo Hanke
title	An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
title_short	An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
title_full	An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
title_fullStr	An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
title_full_unstemmed	An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
title_sort	alpaca nanobody neutralizes sars-cov-2 by blocking receptor interaction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5d6d86e0a27242f592c4fcf292d06534
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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

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