A siRNA-based screen for genes involved in chromosome end protection.

Telomeres are nucleoprotein complexes which protect the ends of linear chromosomes from detection as DNA damage and provide a sequence buffer against replication-associated shortening. In mammals, telomeres consist of repetitive DNA sequence (TTAGGG) and associated proteins. The telomeric core compl...

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Autores principales: Daniel H Lackner, Daniel Durocher, Jan Karlseder
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/5db12512146547bcbd525592bbb9bbe5
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