Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.

Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice.

Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease (HD). HIP14 palmitoylates a specific set of neuronal substrates critical at the synapse, and dow...

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Autores principales: Fiona B Young, Sonia Franciosi, Amanda Spreeuw, Yu Deng, Shaun Sanders, Natalie C M Tam, Kun Huang, Roshni R Singaraja, Weining Zhang, Nagat Bissada, Chris Kay, Michael R Hayden
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/5db8172525484d548ab42c775980e410
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https://doaj.org/article/5db8172525484d548ab42c775980e410

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