SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired...

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Autores principales:	Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K. Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea
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spelling	oai:doaj.org-article:5ddb20f26de643ee84cf7f21c6c28eea2021-12-02T16:10:32ZSCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells10.1038/s42003-021-02310-y2399-3642https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02310-yhttps://doaj.org/toc/2399-3642Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired immune response.Toshio KannoTakahiro NakajimaSatoru YokoyamaHikari K. AsouShigemi SasamotoYasuhiro KamiiKoji HayashizakiYasuo OuchiTaishi OnoderaYoshimasa TakahashiKazutaka IkedaYoshinori HasegawaYuki KinjoOsamu OharaToshinori NakayamaYusuke EndoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Toshio Kanno Takahiro Nakajima Satoru Yokoyama Hikari K. Asou Shigemi Sasamoto Yasuhiro Kamii Koji Hayashizaki Yasuo Ouchi Taishi Onodera Yoshimasa Takahashi Kazutaka Ikeda Yoshinori Hasegawa Yuki Kinjo Osamu Ohara Toshinori Nakayama Yusuke Endo SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
description	Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired immune response.
format	article
author	Toshio Kanno Takahiro Nakajima Satoru Yokoyama Hikari K. Asou Shigemi Sasamoto Yasuhiro Kamii Koji Hayashizaki Yasuo Ouchi Taishi Onodera Yoshimasa Takahashi Kazutaka Ikeda Yoshinori Hasegawa Yuki Kinjo Osamu Ohara Toshinori Nakayama Yusuke Endo
author_facet	Toshio Kanno Takahiro Nakajima Satoru Yokoyama Hikari K. Asou Shigemi Sasamoto Yasuhiro Kamii Koji Hayashizaki Yasuo Ouchi Taishi Onodera Yoshimasa Takahashi Kazutaka Ikeda Yoshinori Hasegawa Yuki Kinjo Osamu Ohara Toshinori Nakayama Yusuke Endo
author_sort	Toshio Kanno
title	SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
title_short	SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
title_full	SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
title_fullStr	SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
title_full_unstemmed	SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
title_sort	scd2-mediated monounsaturated fatty acid metabolism regulates cgas-sting-dependent type i ifn responses in cd4+ t cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea
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SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells

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