Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expression.

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Autores principales:	Jasmin Lalonde, Surya A. Reis, Sudhir Sivakumaran, Carl S. Holland, Hendrik Wesseling, John F. Sauld, Begum Alural, Wen-Ning Zhao, Judith A. Steen, Stephen J. Haggarty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ddba3c2cdb2426a93470cf04103e35c
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spelling	oai:doaj.org-article:5ddba3c2cdb2426a93470cf04103e35c2021-12-02T17:06:11ZChemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability10.1038/s41467-017-01750-72041-1723https://doaj.org/article/5ddba3c2cdb2426a93470cf04103e35c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01750-7https://doaj.org/toc/2041-1723The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expression.Jasmin LalondeSurya A. ReisSudhir SivakumaranCarl S. HollandHendrik WesselingJohn F. SauldBegum AluralWen-Ning ZhaoJudith A. SteenStephen J. HaggartyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasmin Lalonde Surya A. Reis Sudhir Sivakumaran Carl S. Holland Hendrik Wesseling John F. Sauld Begum Alural Wen-Ning Zhao Judith A. Steen Stephen J. Haggarty Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
description	The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expression.
format	article
author	Jasmin Lalonde Surya A. Reis Sudhir Sivakumaran Carl S. Holland Hendrik Wesseling John F. Sauld Begum Alural Wen-Ning Zhao Judith A. Steen Stephen J. Haggarty
author_facet	Jasmin Lalonde Surya A. Reis Sudhir Sivakumaran Carl S. Holland Hendrik Wesseling John F. Sauld Begum Alural Wen-Ning Zhao Judith A. Steen Stephen J. Haggarty
author_sort	Jasmin Lalonde
title	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
title_short	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
title_full	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
title_fullStr	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
title_full_unstemmed	Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability
title_sort	chemogenomic analysis reveals key role for lysine acetylation in regulating arc stability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5ddba3c2cdb2426a93470cf04103e35c
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Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

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