Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expression.

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Auteurs principaux: Jasmin Lalonde, Surya A. Reis, Sudhir Sivakumaran, Carl S. Holland, Hendrik Wesseling, John F. Sauld, Begum Alural, Wen-Ning Zhao, Judith A. Steen, Stephen J. Haggarty
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/5ddba3c2cdb2426a93470cf04103e35c
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