Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differen...

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Autores principales: Deivid Carvalho Rodrigues, Emily M. Harvey, Rejitha Suraj, Sarah L. Erickson, Lamees Mohammad, Mengli Ren, Hongrui Liu, Guiqiong He, David R. Kaplan, James Ellis, Guang Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5de70668dec54528b947cdd22f16d0df
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