Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differen...

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Autores principales:	Deivid Carvalho Rodrigues, Emily M. Harvey, Rejitha Suraj, Sarah L. Erickson, Lamees Mohammad, Mengli Ren, Hongrui Liu, Guiqiong He, David R. Kaplan, James Ellis, Guang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5de70668dec54528b947cdd22f16d0df
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spelling	oai:doaj.org-article:5de70668dec54528b947cdd22f16d0df2021-12-02T14:41:05ZMethylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells10.1038/s41467-020-15941-22041-1723https://doaj.org/article/5de70668dec54528b947cdd22f16d0df2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15941-2https://doaj.org/toc/2041-1723Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.Deivid Carvalho RodriguesEmily M. HarveyRejitha SurajSarah L. EricksonLamees MohammadMengli RenHongrui LiuGuiqiong HeDavid R. KaplanJames EllisGuang YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deivid Carvalho Rodrigues Emily M. Harvey Rejitha Suraj Sarah L. Erickson Lamees Mohammad Mengli Ren Hongrui Liu Guiqiong He David R. Kaplan James Ellis Guang Yang Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
description	Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.
format	article
author	Deivid Carvalho Rodrigues Emily M. Harvey Rejitha Suraj Sarah L. Erickson Lamees Mohammad Mengli Ren Hongrui Liu Guiqiong He David R. Kaplan James Ellis Guang Yang
author_facet	Deivid Carvalho Rodrigues Emily M. Harvey Rejitha Suraj Sarah L. Erickson Lamees Mohammad Mengli Ren Hongrui Liu Guiqiong He David R. Kaplan James Ellis Guang Yang
author_sort	Deivid Carvalho Rodrigues
title	Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
title_short	Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
title_full	Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
title_fullStr	Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
title_full_unstemmed	Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells
title_sort	methylglyoxal couples metabolic and translational control of notch signalling in mammalian neural stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5de70668dec54528b947cdd22f16d0df
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Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

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