A probabilistic model of local sequence alignment that simplifies statistical significance estimation.
Sequence database searches require accurate estimation of the statistical significance of scores. Optimal local sequence alignment scores follow Gumbel distributions, but determining an important parameter of the distribution (lambda) requires time-consuming computational simulation. Moreover, optim...
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2008
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| Accès en ligne: | https://doaj.org/article/5dfd88e407dc49c6b637624e120208de |
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