α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model.

α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model.

Chagas disease, caused by the parasite Trypanosoma cruzi, is considered endemic in more than 20 countries but lacks both an approved vaccine and limited treatment for its chronic stage. Chronic infection is most harmful to human health because of long-term parasitic infection of the heart. Here we s...

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Main Authors: Gisele Macêdo Rodrigues da Cunha, Maíra Araújo Azevedo, Denise Silva Nogueira, Marianna de Carvalho Clímaco, Edward Valencia Ayala, Juan Atilio Jimenez Chunga, Raul Jesus Ynocente La Valle, Lucia Maria da Cunha Galvão, Egler Chiari, Carlos Ramon Nascimento Brito, Rodrigo Pedro Soares, Paula Monalisa Nogueira, Ricardo Toshio Fujiwara, Ricardo Gazzinelli, Robert Hincapie, Carlos-Sanhueza Chaves, Fabricio Marcus Silva Oliveira, M G Finn, Alexandre Ferreira Marques
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Online Access:https://doaj.org/article/5e151268acdb46dfbf28a814c81a6e28
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