Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.
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Nature Portfolio
2021
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oai:doaj.org-article:5e15572a162f473290932a34e9eb1ffa2021-12-02T16:35:07ZTracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS10.1038/s41467-021-25040-52041-1723https://doaj.org/article/5e15572a162f473290932a34e9eb1ffa2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25040-5https://doaj.org/toc/2041-1723Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.Aartik SarmaStephanie A. ChristensonAshley ByrneEran MickAngela Oliveira PiscoCatherine DeVoeThomas DeissRajani GhaleBeth Shoshana ZhaAlexandra TsitsiklisAlejandra JaureguiFarzad MoazedAngela M. DetweilerNatasha SpottiswoodePratik SinhaNorma NeffMichelle TanPaula Hayakawa SerpaAndrew WillmoreK. Mark AnselJennifer G. WilsonAleksandra LeligdowiczEmily R. SiegelMarina SirotaJoseph L. DeRisiMichael A. MatthayCOMET ConsortiumCarolyn M. HendricksonKirsten N. KangelarisMatthew F. KrummelPrescott G. WoodruffDavid J. ErleCarolyn S. CalfeeCharles R. LangelierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| description |
Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone. |
| format |
article |
| author |
Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier |
| author_facet |
Aartik Sarma Stephanie A. Christenson Ashley Byrne Eran Mick Angela Oliveira Pisco Catherine DeVoe Thomas Deiss Rajani Ghale Beth Shoshana Zha Alexandra Tsitsiklis Alejandra Jauregui Farzad Moazed Angela M. Detweiler Natasha Spottiswoode Pratik Sinha Norma Neff Michelle Tan Paula Hayakawa Serpa Andrew Willmore K. Mark Ansel Jennifer G. Wilson Aleksandra Leligdowicz Emily R. Siegel Marina Sirota Joseph L. DeRisi Michael A. Matthay COMET Consortium Carolyn M. Hendrickson Kirsten N. Kangelaris Matthew F. Krummel Prescott G. Woodruff David J. Erle Carolyn S. Calfee Charles R. Langelier |
| author_sort |
Aartik Sarma |
| title |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_short |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_full |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_fullStr |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_full_unstemmed |
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS |
| title_sort |
tracheal aspirate rna sequencing identifies distinct immunological features of covid-19 ards |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5e15572a162f473290932a34e9eb1ffa |
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